How does Tamiflu Work?
Tamiflu -- General Information
(oseltamivir phosphate) is an antiviral drug marketed by the
Swiss pharmaceutical company Roche. It is a neuraminidase
inhibitors (similar to Relenza) and can shorten the duration
and lessen the severity of several types of influenza.
at Roche synthesize oseltamivir from shikimic acid, using a specific
type of star anise that grows in four mountain provinces (Guanxi,
Sichuan, Yunnan and Guizhou) of southwest China. The manufacture
of Tamiflu involves a complex, 10-step process that takes approximately
6-8 months to complete.
can't stop the flu entirely. However, studies have shown that
if you take it within 48 hours of showing symptoms, it
can shorten the duration of the flu (strains A and B).
is the Target for the Tamiflu Drug?
are two molecules on the influenza virus surface that are critical
to its spread: hemagglutinin H and neuraminidase N. Neuraminidase
helps the flu virus break through the cell membrane so it can
move on to other cells and replicate itself.
(oseltamivir) is an inhibitor of influenza neuraminidase that
binds to the enzyme active site.
Relenza (zanamivir) is also an inhibitor of influenza neuraminidase
that binds to the enzyme active site. (Relenza is GlaxoSmithKline's
trade name; zanamivir is the generic name.) Unlike Tamiflu, which
is given orally, Relenza is usually administered by inhalation,
or can be injected.
binds to the active site on neuraminidase (Sialidase).
helps the flu virus break through the cell membrane so it
can move on to other cells and replicate itself. Tamiflu
inhibits the neuraminidase protein, so that the virus can't
leave the cell to infect other cells.
is a homotetramer --Each of the four protein chains in the
tetramer has a catalytic site, and is able to bind Tamiflu
The secondary structure is mostly beta, consisting of several
beta sheets with three short alpha helices (Beta Strands,
Alpha Helices). * The residues contacting the Tamiflu inhibitory
substrate analog are highly conserved
is the structure of the tamiflu molecule?
[Tamiflu structure shown using the JMol
is the Structure of Tamiflu?
the right mouse button with the cursor over the image-->
--> Schemes --> CPK Spacefill
on the left mouse button and rotate the Tamiflu structure.
3-D Structure of Relenza click